NEIM-15 AN EXCEPTION TO THE METASTATIC RULE: A NON-ENHANCING MIDBRAIN LESION DUE TO METASTATIC FIBROMYXOID SARCOMA WITH EXTENSIVEINFLAMMATORY INFILTRATE
نویسندگان
چکیده
Abstract Metastases from extra-CNS sites typically enhance on MR after the administration of gadolinium-based contrast agents due to disruption blood-brain barrier. Fibromyxoid sarcoma involving brain is extremely rare, with only a few reported cases manifesting as well-circumscribed enhancing masses. Here, we report an rare non-enhancing metastasis secondary already sarcoma. A 44-year-old woman gluteal fibromyxoid metastatic cervical paraspinal muscles and adrenal gland treated ipilimumab/nivolumab presented diplopia was found have 8 mm T2-hyperintense midbrain lesion without enhancement or mass effect. An inflammatory etiology associated checkpoint inhibitor therapy suspected, she IV methylprednisolone 1 g daily for 3 days followed by oral prednisone taper, immunoglobulin, plasma exchange improvement. The steadily grew over 15 months follow up, eventually bilateral medial thalami demonstrating diffusion restriction in midbrain, but never showing gadolinium enhancement. imaging reminiscent peripheral brainstem band-like lesions leptomeningeal lung cancer, however CSF cytology repeatedly normal, extensive infectious testing. Her neurologic disability continued progress, development oculomotor nerve palsies, dysarthria, depressed level alertness, devolving into non-convulsive status epilepticus requiring intubation. She died six onset symptoms. At autopsy, histologic immunohistochemical evaluation revealed (MUC-4 positive, TAOK1-FUS fusion) centered periventricular aqueduct accompanying disseminated single-cell infiltration throughout midbrain. background parenchyma were notable voluminous microglial activation histiocytic infiltrate. In sum, this case represents radiographically unique which pathologic exam showed robust changes far out proportion tumor present.
منابع مشابه
REGRESSION OF METASTATIC NEUROBLASTOMA TO GANGLIONEUROMA
The spontaneous regression of neuroblastoma to ganlioneuroma is a rare occurrence. Reviewing the literature, we found no more than 12casesreported.'•2.9.,o.'4.1s We report a case of metastatic neuroblastoma of multifocal skeletal and soft tissue areas with gross deformities which regressed to ganglioneuroma, with good prognosis.
متن کاملPleomorphic sarcoma metastatic to the duodenum?
We read with interest Hawasli et al. report of a pleomorphic sarcoma metastatic to the left atrium. However, we suspect that the true site of origin is unknown, and may in fact be the heart. There are several reasons for this: the histological appearance is similar to left atrial tumors that have already been reported; the left atrium, is the most common site of cardiac pleomorphic sarcoma; all...
متن کاملCardiac sarcoma metastatic to the brain.
Cardiac sarcomas are rare primary cardiac tumors. Because of the few reported cases and relatively poor prognosis of primary cardiac sarcomas, the metastatic potential and behavior of these tumors is not fully understood. In one reported case of cardiac sarcoma metastasizing to the brain (1), the primary tumor could not be resected because of the patient’s poor medical condition and the concurr...
متن کاملAn ulcerated lesion due to HSV-2 infection with a CD56+ cell predominant inflammatory infiltrate.
CD56+ rich inflammatory infiltrates have been described in several cutaneous inflammatory conditions. However, CD56+ cells rarely account for more than 10% of the cells in such infiltrates. In certain conditions, such as insect bites or infection with herpes virus, CD56+ cells can be up to 43% of the cells in the infiltrate. This contrasts with what is observed in natural killer (NK)-cell lymph...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuro-oncology advances
سال: 2023
ISSN: ['2632-2498']
DOI: https://doi.org/10.1093/noajnl/vdad070.064